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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASP8
All Species:
20
Human Site:
S424
Identified Species:
44
UniProt:
Q14790
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14790
NP_001073593.1
479
55391
S424
E
G
T
W
Y
I
Q
S
L
C
Q
S
L
R
E
Chimpanzee
Pan troglodytes
Q5IS54
277
31588
K224
Q
S
L
C
A
M
L
K
Q
Y
A
D
K
L
E
Rhesus Macaque
Macaca mulatta
XP_001091080
569
65150
S514
E
G
T
W
Y
I
Q
S
L
C
Q
S
L
R
E
Dog
Lupus familis
XP_545593
484
55003
S423
K
G
S
W
Y
I
Q
S
L
C
N
R
L
K
S
Cat
Felis silvestris
Mouse
Mus musculus
O89110
480
55338
S426
N
G
T
W
Y
I
Q
S
L
C
Q
S
L
R
E
Rat
Rattus norvegicus
P55213
277
31473
K224
Q
S
L
C
A
M
L
K
L
Y
A
H
K
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513568
471
53077
S416
K
G
T
W
Y
I
Q
S
L
C
H
H
L
R
N
Chicken
Gallus gallus
Q98943
424
47941
D371
V
F
A
E
D
S
R
D
T
H
V
A
D
M
L
Frog
Xenopus laevis
P55866
282
32106
S229
D
G
S
W
F
I
Q
S
L
C
K
M
I
K
L
Zebra Danio
Brachydanio rerio
NP_571585
476
54945
E423
E
G
S
I
F
I
Q
E
L
C
K
K
M
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42573
503
56598
A440
R
G
S
W
F
I
Q
A
V
C
E
V
F
S
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
26.1
79.4
38.6
N.A.
67.2
25.8
N.A.
56.5
24.2
23.1
42.5
N.A.
N.A.
N.A.
21.4
N.A.
Protein Similarity:
100
38
82
58
N.A.
79.5
38.4
N.A.
72.2
45.7
35.9
59.5
N.A.
N.A.
N.A.
40.1
N.A.
P-Site Identity:
100
6.6
100
60
N.A.
93.3
13.3
N.A.
73.3
0
46.6
46.6
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
100
20
100
80
N.A.
93.3
26.6
N.A.
80
13.3
86.6
73.3
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
19
0
0
10
0
0
19
10
0
0
0
% A
% Cys:
0
0
0
19
0
0
0
0
0
73
0
0
0
0
0
% C
% Asp:
10
0
0
0
10
0
0
10
0
0
0
10
10
0
0
% D
% Glu:
28
0
0
10
0
0
0
10
0
0
10
0
0
10
55
% E
% Phe:
0
10
0
0
28
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
73
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
10
19
0
0
0
% H
% Ile:
0
0
0
10
0
73
0
0
0
0
0
0
10
0
0
% I
% Lys:
19
0
0
0
0
0
0
19
0
0
19
10
19
19
0
% K
% Leu:
0
0
19
0
0
0
19
0
73
0
0
0
46
19
19
% L
% Met:
0
0
0
0
0
19
0
0
0
0
0
10
10
10
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
19
0
0
0
0
0
73
0
10
0
28
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
10
0
0
0
0
10
0
37
0
% R
% Ser:
0
19
37
0
0
10
0
55
0
0
0
28
0
10
10
% S
% Thr:
0
0
37
0
0
0
0
0
10
0
0
0
0
0
10
% T
% Val:
10
0
0
0
0
0
0
0
10
0
10
10
0
0
0
% V
% Trp:
0
0
0
64
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
46
0
0
0
0
19
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _